MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ*
نویسندگان
چکیده
منابع مشابه
MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ*
MutSbeta (MSH2-MSH3) mediates repair of insertion-deletion heterologies but also triggers triplet repeat expansions that cause neurological diseases. Like other DNA metabolic activities, MutSbeta interacts with proliferating cell nuclear antigen (PCNA) via a conserved motif (QXX(L/I)XXFF). We demonstrate that MutSbeta-PCNA complex formation occurs with an affinity of approximately 0.1 microM an...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.104125